Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 10/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NAAA | Q02083 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2361098 | 0.81 | HTT (0.91) | HTTSMN1; SMN2NPC1RAB9AEPHX2 | |
| SCHEMBL11697547 | 0.79 | POLB (0.54) | HTTSMN1; SMN2NPC1RAB9AEPHX2 | |
| SCHEMBL16596334 | 0.78 | DEGS1 (0.62) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL18274878 | 0.78 | SMN1; SMN2 (0.59) | HTTSMN1; SMN2NPC1RAB9AEPHX2 | |
| SCHEMBL11697605 | 0.78 | NAAA (0.53) | HTTSMN1; SMN2NPC1RAB9AEPHX2 | |
| SCHEMBL3662937 | 0.77 | DNM2 (0.50) | HTTSMN1; SMN2NAAA | |
| SCHEMBL30567117 | 0.76 | DEGS1 (0.67) | HTTSMN1; SMN2NPC1RAB9AEPHX2 | |
| SCHEMBL26758609 | 0.76 | RAB9A (0.65) | HTTSMN1; SMN2NPC1RAB9AEPHX2 | |
| SCHEMBL22581730 | 0.76 | DEGS1 (0.67) | HTTSMN1; SMN2NPC1RAB9AEPHX2 | |
| SCHEMBL6906687 | 0.76 | ROCK2 (0.60) | SMN1; SMN2NPC1RAB9AEPHX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230075776-A1 | ANTAGONIST OF THE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) FOR USE IN THE TREATMENT OR THE PREVENTION OF SKELETAL DISORDERS LINKED WITH ABNORMAL ACTIVATION OF FGFR3 | UNIVERSITÉ PARIS CITÉ (FR) | 2023-03-09 | — | — | US | disclosed |
| US-11357778-B2 | Antagonist of the fibroblast growth factor receptor 3 (FGFR3) for use in the treatment or the prevention of skeletal disorders linked with abnormal activation of FGFR3 | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2022-06-14 | — | — | US | disclosed |
| US-20220031696-A9 | ANTAGONIST OF THE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) FOR USE IN THE TREATMENT OR THE PREVENTION OF SKELETAL DISORDERS LINKED WITH ABNORMAL ACTIVATION OF FGFR3 | UNIVERSITÉ PARIS CITÉ (FR) | 2022-02-03 | — | — | US | disclosed |
| US-20200246337-A1 | ANTAGONIST OF THE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) FOR USE IN THE TREATMENT OR THE PREVENTION OF SKELETAL DISORDERS LINKED WITH ABNORMAL ACTIVATION OF FGFR3 | INSTITUT NATIONAL DE LA SANTE ET DE LA RECH MEDICALE (INSERM) (FR) | 2020-08-06 | — | — | US | disclosed |
| US-20180161327-A1 | ANTAGONIST OF THE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) FOR USE IN THE TREATMENT OR THE PREVENTION OF SKELETAL DISORDERS LINKED WITH ABNORMAL ACTIVATION OF FGFR3 | ASSISTANCE PUBLIQUE HOPITAUX DE PARIS (FR) | 2018-06-14 | — | — | US | disclosed |
| US-9931341-B2 | Antagonist of the fibroblast growth factor receptor 3 (FGFR3) for use in the treatment or the prevention of skeletal disorders linked with abnormal activation of FGFR3 | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2018-04-03 | — | — | US | disclosed |
| EP-2790718-B1 | ANTAGONIST OF THE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) FOR USE IN THE TREATMENT OR THE PREVENTION OF SKELETAL DISORDERS LINKED WITH ABNORMAL ACTIVATION OF FGFR3 | INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECH MÉDICALE (INSERM) (FR) | 2018-02-07 | — | — | EP | disclosed |
| US-20160051549-A1 | ANTAGONIST OF THE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) FOR USE IN THE TREATMENT OR THE PREVENTION OF SKELETAL DISORDERS LINKED WITH ABNORMAL ACTIVATION OF FGFR3 | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2016-02-25 | — | — | US | disclosed |
| US-20150011560-A1 | ANTAGONIST OF THE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) FOR USE IN THE TREATMENT OR THE PREVENTION OF SKELETAL DISORDERS LINKED WITH ABNORMAL ACTIVATION OF FGFR3 | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2015-01-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150011560-A1 | ANTAGONIST OF THE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) FOR USE IN THE TREATMENT OR THE PREVENTION OF SKELETAL DISORDERS LINKED WITH ABNORMAL ACTIVATION OF FGFR3 | FGFR3, FGFR1, FGFR2 | HTT 2103/4885SMN1; SMN2 227/4885NPC1 4475/4885 |
| US-20200246337-A1 | ANTAGONIST OF THE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) FOR USE IN THE TREATMENT OR THE PREVENTION OF SKELETAL DISORDERS LINKED WITH ABNORMAL ACTIVATION OF FGFR3 | FGFR3, FGFR1, FGFR2 | HTT 2093/4885SMN1; SMN2 254/4885NPC1 4498/4885 |
| US-11357778-B2 | Antagonist of the fibroblast growth factor receptor 3 (FGFR3) for use in the treatment or the prevention of skeletal disorders linked with abnormal activation of FGFR3 | FGFR3, FGFR1, FGFR2 | HTT 2093/4885SMN1; SMN2 254/4885NPC1 4498/4885 |
| US-20160051549-A1 | ANTAGONIST OF THE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) FOR USE IN THE TREATMENT OR THE PREVENTION OF SKELETAL DISORDERS LINKED WITH ABNORMAL ACTIVATION OF FGFR3 | FGFR3, FGFR1, FGFR2 | HTT 2117/4885SMN1; SMN2 258/4885NPC1 4505/4885 |
| US-20230075776-A1 | ANTAGONIST OF THE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) FOR USE IN THE TREATMENT OR THE PREVENTION OF SKELETAL DISORDERS LINKED WITH ABNORMAL ACTIVATION OF FGFR3 | FGFR3, FGFR1, FGFR2 | HTT 2117/4885SMN1; SMN2 258/4885NPC1 4505/4885 |
| US-20220031696-A9 | ANTAGONIST OF THE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) FOR USE IN THE TREATMENT OR THE PREVENTION OF SKELETAL DISORDERS LINKED WITH ABNORMAL ACTIVATION OF FGFR3 | FGFR3, FGFR1, FGFR2 | HTT 2093/4885SMN1; SMN2 254/4885NPC1 4498/4885 |
| US-20180161327-A1 | ANTAGONIST OF THE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) FOR USE IN THE TREATMENT OR THE PREVENTION OF SKELETAL DISORDERS LINKED WITH ABNORMAL ACTIVATION OF FGFR3 | FGFR3, FGFR1, FGFR2 | HTT 2117/4885SMN1; SMN2 258/4885NPC1 4505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.