Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6199771 | 0.74 | MAPT (0.68) | KDM4EMAPTHSD17B10TDP1L3MBTL1 | |
| SCHEMBL6199260 | 0.62 | KDM4E (0.44) | KDM4EMAPTHSD17B10TDP1L3MBTL1 | |
| SCHEMBL6195101 | 0.56 | KDM4E (0.41) | KDM4EMAPTHSD17B10TDP1L3MBTL1 | |
| SCHEMBL3882223 | 0.55 | PTGIR (0.38) | KDM4EHSD17B10 | |
| SCHEMBL6194351 | 0.54 | HTR2C (0.61) | — | |
| SCHEMBL6195265 | 0.54 | PTGIR (0.32) | KDM4EMAPTHSD17B10TDP1L3MBTL1 | |
| SCHEMBL4125843 | 0.54 | MAPK14 (0.37) | MAPT | |
| SCHEMBL6196389 | 0.54 | DRD4 (0.38) | KDM4EMAPTHSD17B10TDP1L3MBTL1 | |
| SCHEMBL6195098 | 0.54 | PLK4 (0.40) | KDM4EMAPTHSD17B10TDP1L3MBTL1 | |
| SCHEMBL6076416 | 0.54 | MAPK14 (0.51) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0990650-B1 | TRICYCLIC PYRROLE OR PYRAZOLE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2005-08-17 | — | — | EP | disclosed |
| US-6245796-B1 | NERVOUS SYSTEM DISORDERS; SEXUAL DISORDERS; SLEEP DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2001-06-12 | — | — | US | disclosed |
| EP-0990650-A1 | TRICYCLIC PYRROLE OR PYRAZOLE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2000-04-05 | — | — | EP | disclosed |