Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 6/20 | 0.48 |
| ▸ | MMP9 | P14780 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MMP1 | P03956 | 5/20 | 0.42 |
| ▸ | MMP13 | P45452 | 4/20 | 0.42 |
| ▸ | BMP1 | P13497 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 3/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1601963 | 0.93 | MMP2 (0.48) | MMP2MMP9ALDH1A1POLBMMP1 | |
| SCHEMBL1602818 | 0.91 | MMP2 (0.44) | MMP2MMP9ALDH1A1POLBMMP1 | |
| SCHEMBL1602742 | 0.90 | MMP2 (0.47) | MMP2MMP9ALDH1A1POLBMMP1 | |
| SCHEMBL1602483 | 0.89 | MMP2 (0.44) | MMP2MMP9ALDH1A1POLBMMP1 | |
| SCHEMBL1601507 | 0.89 | MMP2 (0.47) | MMP2MMP9ALDH1A1POLBMMP1 | |
| SCHEMBL5770237 | 0.86 | MMP2 (0.41) | MMP2MMP9ALDH1A1POLBMMP1 | |
| SCHEMBL1602159 | 0.86 | MMP2 (0.42) | MMP2MMP9ALDH1A1POLBMMP1 | |
| SCHEMBL5771248 | 0.83 | MMP9 (0.40) | MMP2MMP9ALDH1A1POLBMMP1 | |
| SCHEMBL1602356 | 0.83 | BCL2 (0.40) | MMP2MMP9ALDH1A1POLBMMP1 | |
| SCHEMBL1601222 | 0.81 | MMP2 (0.46) | MMP2MMP9ALDH1A1POLBMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1159278-B1 | INHIBITORS OF ASPARTYL PROTEASE | VERTEX PHARMA (US) | 2005-11-30 | — | — | EP | disclosed |