Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 17/20 | 0.54 |
| ▸ | HTR2C | P28335 | 15/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6201535 | 0.93 | HTR2A (0.55) | HTR2AHTR2CKMT2ANPSR1 | |
| SCHEMBL6198115 | 0.83 | HTR2A (0.57) | HTR2AHTR2CNPSR1 | |
| SCHEMBL6222801 | 0.82 | HTR2A (0.54) | HTR2AHTR2CMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6201230 | 0.81 | HTR2A (0.61) | HTR2AHTR2C | |
| SCHEMBL6200652 | 0.79 | HTR2A (0.66) | HTR2AHTR2C | |
| SCHEMBL6199168 | 0.79 | HTR2A (0.58) | HTR2AHTR2C | |
| SCHEMBL6199690 | 0.78 | HTR2A (0.59) | HTR2AHTR2C | |
| SCHEMBL6199479 | 0.77 | HTR2A (0.64) | HTR2AHTR2C | |
| SCHEMBL6194256 | 0.76 | RAB9A (0.49) | HTR2AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6222572 | 0.76 | HTR2A (0.56) | HTR2AHTR2CMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509505-A2 | SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2005-03-02 | — | — | EP | claimed |
| WO-2003062206-A2 | SMALL MOLECULE MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2003-07-31 | — | — | WO | claimed |