Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 16/20 | 0.55 |
| ▸ | HTR2C | P28335 | 14/20 | 0.54 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6199536 | 0.93 | HTR2A (0.54) | HTR2AHTR2CNPSR1KMT2A | |
| SCHEMBL6198115 | 0.90 | HTR2A (0.57) | HTR2AHTR2CCNR1NPC1GAA | |
| SCHEMBL6194256 | 0.83 | RAB9A (0.49) | HTR2ANPC1MAPTPKMRAB9A | |
| SCHEMBL6222801 | 0.83 | HTR2A (0.54) | HTR2AHTR2CNPC1MAPTRAB9A | |
| SCHEMBL6201230 | 0.82 | HTR2A (0.61) | HTR2AHTR2C | |
| SCHEMBL6198102 | 0.81 | CNR1 (0.45) | HTR2AHTR2CCNR1NPC1MAPT | |
| SCHEMBL6200652 | 0.80 | HTR2A (0.66) | HTR2AHTR2C | |
| SCHEMBL6199168 | 0.80 | HTR2A (0.58) | HTR2AHTR2C | |
| SCHEMBL6199690 | 0.79 | HTR2A (0.59) | HTR2AHTR2C | |
| SCHEMBL5946644 | 0.78 | HTR2A (0.50) | HTR2AHTR2CCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509505-A2 | SMALL MOLECULE MODULATORS OF THE 5−HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2005-03-02 | — | — | EP | claimed |
| WO-2003062206-A2 | SMALL MOLECULE MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2003-07-31 | — | — | WO | claimed |