Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.40 |
| ▸ | GCGR | P47871 | 4/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | FRK | P42685 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.38 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10558941 | 0.80 | ALDH1A1 (0.44) | SMN1; SMN2NPC1RAB9AMAPK13GCGR | |
| SCHEMBL1954237 | 0.79 | MTOR (0.42) | SMN1; SMN2KDM4ENPC1RAB9AMAPK13 | |
| SCHEMBL15029205 | 0.78 | MAPK1 (0.42) | SMN1; SMN2KDM4ENPC1RAB9AMAPK13 | |
| SCHEMBL28279252 | 0.76 | ALDH1A1 (0.46) | SMN1; SMN2KDM4ENPC1RAB9AMAPK13 | |
| Hydrochloric Acid SCHEMBL10555133 | 0.74 | KDM4E (0.47) | SMN1; SMN2KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL2821562 | 0.73 | KDM4E (0.39) | SMN1; SMN2KDM4ENPC1RAB9AMAPK13 | |
| SCHEMBL26500690 | 0.73 | SMN1; SMN2 (0.39) | SMN1; SMN2KDM4ENPC1RAB9AMAPK13 | |
| SCHEMBL26093883 | 0.73 | KDM4E (0.44) | SMN1; SMN2KDM4ENPC1RAB9AMAPK13 | |
| SCHEMBL15332789 | 0.72 | KDM4E (0.38) | SMN1; SMN2KDM4ENPC1RAB9AMAPK13 | |
| SCHEMBL7141855 | 0.72 | KDM4E (0.45) | SMN1; SMN2KDM4ENPC1RAB9AMAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503998-A1 | HETEROARYL SUBSTITUTED SPIROCYCLIC SUFAMIDES FOR INHIBITION OF GAMMA SECRETASE | MERCK SHARP & DOHME LTD. (GB) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003093252-A1 | HETEROARYL SUBSTITUTED SPIROCYCLIC SULFAMIDES FOR INHIBITION OF GAMMA SECRETASE | MERCK SHARP & DOHME LIMITED (GB) | 2003-11-13 | — | — | WO | disclosed |
| CN-1378544-A | Substituted azoles compounds | NOVARTIS AG (CH) | 2002-11-06 | — | — | CN | disclosed |