Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 2/20 | 0.37 |
| ▸ | HMGB1 | P09429 | 3/20 | 0.36 |
| ▸ | CXCL12 | P48061 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.31 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.31 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.31 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.31 |
| ▸ | SELL | P14151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7406801 | 0.83 | ALDH1A1 (0.39) | ALDH1A1HPGDHSD17B10PTPN1PTPN2 | |
| SCHEMBL6199276 | 0.79 | PTPN1 (0.41) | ALDH1A1HPGDHSD17B10PTPN1HMGB1 | |
| SCHEMBL6199961 | 0.77 | GABRA1 (0.40) | ALDH1A1HPGDHSD17B10PTPN1PTPN2 | |
| SCHEMBL6197773 | 0.76 | HMGB1 (0.39) | ALDH1A1HPGDHSD17B10PTPN1PTPN2 | |
| SCHEMBL7496401 | 0.76 | ALDH1A1 (0.34) | ALDH1A1HPGDHSD17B10PTPN1PTPN2 | |
| SCHEMBL6198273 | 0.76 | SELL (0.42) | ALDH1A1HPGDHSD17B10HMGB1CXCL12 | |
| SCHEMBL6200810 | 0.75 | NPSR1 (0.40) | ALDH1A1HPGDHSD17B10PTPN1PTPN2 | |
| SCHEMBL6202597 | 0.74 | GABRA1 (0.37) | ALDH1A1HPGDHSD17B10PTPN1PTPN2 | |
| SCHEMBL6199554 | 0.71 | ALDH1A1 (0.33) | ALDH1A1HPGDHSD17B10PTPN1PTPN2 | |
| SCHEMBL6199994 | 0.71 | ALDH1A1 (0.36) | ALDH1A1HPGDHSD17B10HMGB1CXCL12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1130017-B1 | Azole derivatives and their use as superoxide radical inhibitors | OTSUKA PHARMA CO LTD (JP) | 2005-06-15 | — | — | EP | disclosed |
| EP-0934937-B1 | Azole derivatives as superoxide radical inhibitor | OTSUKA PHARMA CO LTD (JP) | 2002-02-27 | — | — | EP | disclosed |
| US-RE37556-E1 | (ALKOXYPHENYL)THIAZOLE DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2002-02-19 | — | — | US | disclosed |
| EP-1130017-A2 | Azole derivatives and their use as superoxide radical inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2001-09-05 | — | — | EP | disclosed |
| US-6080764-A | PROTECTING VARIOUS TISSUE CELLS FROM DISTURBANCES ASSOCIATED WITH ISCHEMIA AND BLOOD REPERFUSION IN HEART, BRAIN, KIDNEY, LUNG AND DIGESTIVE TRACT BY INHIBITING SUPEROXIDE-RELEASE BY NEUTROPHILIC LEUKOCYTES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2000-06-27 | — | — | US | disclosed |
| EP-0934937-A1 | Azole derivatives as superoxide radical inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-11 | — | — | EP | disclosed |
| US-5677319-A | THIAZOLE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-10-14 | — | — | US | disclosed |
| US-5643932-A | PREVENTS CELL DAMAGE AFTER ISCHEMIA AND RE-PERFUSION, SUBSTITUTED THIAZOLES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-01 | — | — | US | disclosed |
| EP-0513387-A1 | ACTIVE OXYGEN INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-19 | — | — | EP | disclosed |