Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6201423 | 0.93 | MAPT (0.48) | ALDH1A1SMN1; SMN2MAPTADORA3HTT | |
| SCHEMBL6201427 | 0.76 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL27875502 | 0.76 | SMN1; SMN2 (0.52) | ALDH1A1SMN1; SMN2MAPTADORA3LMNA | |
| SCHEMBL28024258 | 0.75 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL9476034 | 0.72 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL9475602 | 0.72 | MAPT (0.49) | ALDH1A1SMN1; SMN2MAPTHTTLMNA | |
| SCHEMBL10911202 | 0.71 | POLB (0.40) | ALDH1A1SMN1; SMN2MAPTLMNAGAA | |
| SCHEMBL10736837 | 0.71 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2MAPTHTTMEN1 | |
| SCHEMBL10826912 | 0.71 | CACNA1C (0.54) | HTTGAAMEN1KMT2ATSHR | |
| SCHEMBL6194820 | 0.71 | MAPT (0.47) | ALDH1A1SMN1; SMN2MAPTHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021185-A4 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 2005-09-07 | — | — | EP | disclosed |
| EP-1021185-A1 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1997042956-A1 | DIDHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-11-20 | — | — | WO | disclosed |