Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 13/20 | 0.72 |
| ▸ | APOB | P04114 | 9/20 | 0.72 |
| ▸ | SMO | Q99835 | 12/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7515374 | 0.89 | MTTP (0.57) | MTTPAPOBSMO | |
| SCHEMBL6199234 | 0.89 | MTTP (0.75) | MTTPAPOBSMO | |
| SCHEMBL6201985 | 0.88 | MTTP (0.72) | MTTPAPOBSMO | |
| SCHEMBL6198944 | 0.84 | MTTP (0.78) | MTTPAPOBSMO | |
| SCHEMBL6195985 | 0.84 | MTTP (0.78) | MTTPAPOBSMO | |
| SCHEMBL6201574 | 0.84 | MTTP (1.00) | MTTPAPOBSMO | |
| SCHEMBL6198757 | 0.84 | MTTP (1.00) | MTTPAPOBSMO | |
| SCHEMBL6198932 | 0.84 | MTTP (1.00) | MTTPAPOBSMO | |
| SCHEMBL13591617 | 0.82 | SMO (0.80) | MTTPAPOBSMO | |
| SCHEMBL6198258 | 0.81 | MTTP (0.72) | MTTPAPOBSMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259484-B1 | CARBOXAMIDES USEFUL AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND OF APOLIPOPROTEIN B SECRETION | NOVARTIS AG (CH) | 2005-05-18 | — | — | EP | disclosed |
| US-6878707-B2 | Carboxamides useful as inhibitors of microsomal triglyceride transfer protein and of apolipoprotein b secretion | NOVARTIS AG (CH) | 2005-04-12 | — | — | US | disclosed |
| US-20030109700-A1 | Carboxamides useful as inhinitors of microsomal triglyceride transfer protein and of apolipoprotein b secretion | NOVARTIS AG (CH) | 2003-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030109700-A1 | Carboxamides useful as inhinitors of microsomal triglyceride transfer protein and of apolipoprotein b secretion | APOB, CETP, MTTP | MTTP 3/4885APOB 1/4885SMO 4266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.