Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 13/20 | 0.57 |
| ▸ | APOB | P04114 | 10/20 | 0.57 |
| ▸ | SMO | Q99835 | 10/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6200230 | 0.89 | MTTP (0.72) | MTTPAPOBSMO | |
| SCHEMBL7505684 | 0.88 | MTTP (0.59) | MTTPAPOBSMO | |
| SCHEMBL7561317 | 0.84 | MTTP (0.78) | MTTPAPOBSMO | |
| SCHEMBL2990416 | 0.78 | MTTP (0.67) | MTTPAPOBSMO | |
| SCHEMBL6199234 | 0.78 | MTTP (0.75) | MTTPAPOBSMO | |
| SCHEMBL6201985 | 0.77 | MTTP (0.72) | MTTPAPOBSMO | |
| SCHEMBL6198944 | 0.73 | MTTP (0.78) | MTTPAPOBSMO | |
| SCHEMBL6195985 | 0.73 | MTTP (0.78) | MTTPAPOBSMO | |
| SCHEMBL6201574 | 0.72 | MTTP (1.00) | MTTPAPOBSMO | |
| SCHEMBL6198932 | 0.72 | MTTP (1.00) | MTTPAPOBSMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259484-A1 | CARBOXAMIDES USEFUL AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND OF APOLIPOPROTEIN B SECRETION | Novartis AG (CH) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001053260-A1 | CARBOXAMIDES USEFUL AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND OF APOLIPOPROTEIN B SECRETION | NOVARTIS AG (CH) | 2001-07-26 | — | — | WO | disclosed |