Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 16/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | WNT3 | P56703 | 1/20 | 0.43 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.43 |
| ▸ | PNMT | P11086 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6200793 | 1.00 | HTR6 (0.50) | HTR6HTR2CHTR2BDRD3WNT3 | |
| SCHEMBL6200791 | 1.00 | HTR6 (0.50) | HTR6HTR2CHTR2BDRD3WNT3 | |
| SCHEMBL6198477 | 0.89 | HTR6 (0.51) | HTR6HTR2CHTR2BDRD3 | |
| SCHEMBL6199954 | 0.89 | HTR6 (0.51) | HTR6HTR2CHTR2BDRD3WNT3 | |
| SCHEMBL6201833 | 0.89 | HTR6 (0.51) | HTR6HTR2CHTR2BDRD3 | |
| SCHEMBL6201849 | 0.89 | HTR6 (0.51) | HTR6HTR2CHTR2BDRD3WNT3 | |
| SCHEMBL6201912 | 0.89 | HTR6 (0.51) | HTR6HTR2CHTR2BDRD3 | |
| SCHEMBL6199846 | 0.89 | HTR6 (0.51) | HTR6HTR2CHTR2BDRD3WNT3 | |
| SCHEMBL6200505 | 0.89 | HTR6 (0.51) | HTR6HTR2CHTR2BDRD3 | |
| SCHEMBL6200053 | 0.89 | HTR6 (0.51) | HTR6HTR2CHTR2BDRD3WNT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351961-B1 | SUBSTITUTED INDOLINES AS 5-HT RECEPTOR LIGANDS | PHARMACIA & UPJOHN CO LLC (US) | 2005-07-27 | — | — | EP | disclosed |