Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5356150 | 0.83 | CHRM2 (0.37) | KCNH2CHRM2CHRM1MMP2GRM5 | |
| SCHEMBL3452817 | 0.82 | CA12 (0.51) | CA12CA1CA2CA7CA9 | |
| SCHEMBL7571307 | 0.81 | APP (0.44) | KCNH2CHRM2CHRM1MMP2MMP9 | |
| SCHEMBL31046612 | 0.81 | CYP2D6 (0.44) | KCNH2CHRM2CHRM1GRM5PTGDR2 | |
| SCHEMBL7581858 | 0.81 | CYP2D6 (0.44) | KCNH2CHRM2CHRM1GRM5PTGDR2 | |
| SCHEMBL5359588 | 0.79 | KMT2A (0.41) | CA12CA1CA2CA7CA9 | |
| SCHEMBL6338672 | 0.79 | KCNH2 (0.46) | LMNAKCNH2MMP2CA12CA1 | |
| SCHEMBL7575151 | 0.78 | CASP3 (0.40) | LMNACA12CA1CA2CA7 | |
| SCHEMBL5038631 | 0.76 | LSS (0.46) | PTGDR2 | |
| SCHEMBL12016065 | 0.76 | LMNA (0.46) | LMNAKCNH2CHRM2CHRM1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977755-B1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 2005-07-13 | — | — | EP | disclosed |
| EP-0977755-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2000-02-09 | — | — | EP | disclosed |
| US-6015813-A | USEFUL IN TREATING A DISEASE IN THE CENTRAL NERVOUS SYSTEM CAUSED BY MALFUNCTIONING OF THE MUSCARINIC CHOLINERGIC SYSTEM. | NOVO NORDISK A/S (DK) | 2000-01-18 | — | — | US | disclosed |
| WO-1998047900-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1998-10-29 | — | — | WO | disclosed |