Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 10/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.48 |
| ▸ | HRH2 | P25021 | 9/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6098033 | 0.90 | THRB (0.44) | HRH1HTR1ADRD4HTR2AOPRM1 | |
| SCHEMBL5965740 | 0.89 | HRH1 (0.44) | HRH1HTR1ADRD4HTR2AOPRM1 | |
| SCHEMBL6095096 | 0.88 | EPHX2 (0.46) | HRH1HTR1ADRD4HTR2AOPRM1 | |
| SCHEMBL6096906 | 0.86 | HRH1 (0.46) | HRH1HTR1ADRD4HTR2AOPRM1 | |
| SCHEMBL6093051 | 0.86 | HRH1 (0.49) | HRH1HTR1ADRD4HTR2AOPRM1 | |
| SCHEMBL6093974 | 0.85 | HRH1 (0.43) | HRH1HTR1ADRD4HTR2AOPRM1 | |
| SCHEMBL6096247 | 0.85 | HRH1 (0.57) | HRH1HTR1ADRD4HTR2AOPRM1 | |
| SCHEMBL6092576 | 0.84 | HRH1 (0.47) | HRH1HTR1ADRD4HTR2AOPRM1 | |
| SCHEMBL6990862 | 0.82 | THRB (0.43) | HRH1HTR1ADRD4HTR2AOPRM1 | |
| SCHEMBL6093983 | 0.81 | ADAM17 (0.40) | HRH1HTR1ADRD4HTR2AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1360187-B1 | 3,7-DIAZABICYCLO(3.3.0)OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2005-06-22 | — | — | EP | disclosed |
| EP-1360187-A1 | 3,7-DIAZABICYCLO(3.3.0)OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | AstraZeneca AB (SE) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002060902-A1 | 3,7-DIAZABICYCLO[3.3.0]OCTANES AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2002-08-08 | — | — | WO | disclosed |