Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 14/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 13/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 13/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7849244 | 0.89 | ITGAL (0.50) | ITGALITGB2ICAM1HSP90AA1ALDH1A1 | |
| SCHEMBL6194517 | 0.86 | ITGAL (0.47) | ITGALITGB2ICAM1ALDH1A1HPGD | |
| SCHEMBL5830859 | 0.85 | ITGAL (0.57) | ITGALITGB2ICAM1HSP90AA1ALDH1A1 | |
| SCHEMBL6198447 | 0.81 | ITGAL (0.48) | ITGALITGB2ICAM1ALDH1A1HPGD | |
| SCHEMBL5830185 | 0.80 | ITGAL (0.50) | ITGALITGB2ICAM1ALDH1A1HPGD | |
| SCHEMBL6196832 | 0.78 | ITGAL (0.62) | ITGALITGB2ICAM1ALDH1A1HPGD | |
| SCHEMBL5836083 | 0.78 | ITGAL (0.41) | ITGALITGB2ICAM1ALDH1A1HPGD | |
| SCHEMBL6200163 | 0.78 | ITGAL (0.43) | ITGALITGB2ICAM1ALDH1A1LMNA | |
| SCHEMBL6196752 | 0.78 | ALDH1A1 (0.44) | ITGALITGB2ICAM1ALDH1A1HPGD | |
| SCHEMBL5829924 | 0.77 | ITGAL (0.64) | ITGALITGB2ICAM1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140814-B1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY AND IMMUNE-SUPPRESSIVE COMPOUNDS | ABBOTT LAB (US) | 2005-05-25 | — | — | EP | claimed |
| US-6878700-B1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES (US) | 2005-04-12 | — | — | US | claimed |
| US-6878700-B1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES (US) | 2005-04-12 | — | — | US | disclosed |
| US-6867203-B2 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES (US) | 2005-03-15 | — | — | US | disclosed |
| US-20040116518-A1 | Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds | ABBOTT LABORATORIES | 2004-06-17 | — | — | US | disclosed |