Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 18/20 | 0.48 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7482395 | 0.86 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL6204481 | 0.85 | CRHR1 (0.45) | CRHR1AAK1 | |
| SCHEMBL6200122 | 0.83 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL5438215 | 0.83 | CRHR1 (0.49) | CRHR1 | |
| SCHEMBL5443459 | 0.81 | CRHR1 (0.57) | CRHR1 | |
| SCHEMBL7474054 | 0.78 | CRHR1 (0.61) | CRHR1 | |
| SCHEMBL6199707 | 0.77 | CRHR1 (0.57) | CRHR1 | |
| SCHEMBL7474568 | 0.73 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL5412266 | 0.73 | CRHR1 (0.61) | CRHR1 | |
| SCHEMBL7479803 | 0.73 | CRHR1 (0.54) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | claimed |