Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | TDO2 | P48775 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16866821 | 0.81 | IDO1 (0.43) | IDO1TDO2SLC6A3AOC3SLC6A2 | |
| SCHEMBL8004553 | 0.78 | CHRNA7 (0.46) | ACHE | |
| SCHEMBL3102669 | 0.75 | TAAR1 (0.41) | CYP2D6TSHR | |
| SCHEMBL6205426 | 0.75 | AOC3 (0.47) | IDO1TDO2SLC6A3AOC3SLC6A2 | |
| SCHEMBL28602446 | 0.75 | IDO1 (0.46) | IDO1TDO2SLC6A3AOC3SLC6A2 | |
| SCHEMBL6202388 | 0.74 | IDO1 (0.44) | IDO1TDO2AOC3ACHEHDAC4 | |
| SCHEMBL28346241 | 0.73 | PTGS2 (0.48) | CYP1A2CYP2C9CYP2C19CYP17A1 | |
| SCHEMBL6141138 | 0.71 | IDO1 (0.38) | IDO1TDO2AOC3ACHEDAO | |
| SCHEMBL24327735 | 0.71 | NPSR1 (0.41) | HTTNPSR1HDAC3HDAC4HDAC1 | |
| SCHEMBL7893366 | 0.71 | ESR1 (0.52) | IDO1TDO2SLC6A3AOC3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |