Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.46 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.46 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.44 |
| ▸ | CHRNG | P07510 | 1/20 | 0.44 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | CHRND | Q07001 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4063476 | 0.80 | MBTD1 (0.46) | MBTD1L3MBTL3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL1205831 | 0.79 | OPRL1 (0.63) | SLC6A2OPRL1CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL3583059 | 0.79 | OPRL1 (0.63) | SLC6A2OPRL1CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL8507420 | 0.79 | OPRL1 (0.63) | SLC6A2OPRL1CYP1A2CYP2C19CYP3A4 | |
| SCHEMBL8074161 | 0.78 | CYP1A2 (0.66) | OPRL1CYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL13039159 | 0.78 | CYP1A2 (0.66) | OPRL1CYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL8074159 | 0.78 | CYP1A2 (0.66) | OPRL1CYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL4193407 | 0.73 | LMNA (0.66) | MBTD1L3MBTL3CHRNA1CHRNGCHRNB1 | |
| SCHEMBL5858340 | 0.71 | IDO1 (0.43) | SLC6A2SLC6A3CYP3A4CYP2D6MAPK1 | |
| SCHEMBL7605334 | 0.71 | IDO1 (0.47) | SLC6A2SLC6A3CYP3A4CYP2D6MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |