Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.58 |
| ▸ | LMNA | P02545 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9725963 | 0.80 | ALDH1A1 (0.67) | ALDH1A1LMNAMAPTPOLBKMT2A | |
| SCHEMBL4476411 | 0.80 | ALDH1A1 (0.71) | ALDH1A1LMNAMAPTPOLBKMT2A | |
| Hydrochloric Acid SCHEMBL3519020 | 0.79 | ALDH1A1 (0.69) | ALDH1A1LMNAMAPTPOLBKMT2A | |
| SCHEMBL4791742 | 0.79 | KMT2A (0.67) | ALDH1A1LMNAMAPTPOLBKMT2A | |
| SCHEMBL14825364 | 0.77 | MAPT (0.57) | ALDH1A1LMNAMAPTRXFP1POLB | |
| SCHEMBL8229849 | 0.76 | ALDH1A1 (0.64) | ALDH1A1LMNAMAPTRXFP1POLB | |
| SCHEMBL19403443 | 0.74 | PSMD14 (0.75) | ALDH1A1LMNAMAPTRXFP1KMT2A | |
| SCHEMBL15503867 | 0.74 | USP2 (0.78) | ALDH1A1LMNAMAPTPOLBHSD17B10 | |
| SCHEMBL17383210 | 0.73 | ALDH1A1 (0.56) | ALDH1A1LMNAMAPTPOLBHSD17B10 | |
| SCHEMBL12500188 | 0.72 | POLB (0.69) | ALDH1A1LMNAMAPTPOLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |