Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8991557 | 0.83 | RET (0.45) | RETMAPK14CAMK1DHDAC6 | |
| SCHEMBL9793697 | 0.74 | RET (0.36) | RETMAPK14CAMK1DHDAC6 | |
| SCHEMBL11602001 | 0.74 | RET (0.42) | RETMAPK14CAMK1DHDAC6 | |
| SCHEMBL12873202 | 0.74 | RET (0.31) | RETMAPK14CAMK1D | |
| SCHEMBL14769002 | 0.72 | CYP2D6 (0.35) | RETMAPK14CAMK1D | |
| SCHEMBL11603418 | 0.72 | RET (0.41) | RETMAPK14CAMK1DHDAC6 | |
| SCHEMBL11604019 | 0.71 | RET (0.40) | RETMAPK14CAMK1DHDAC6 | |
| SCHEMBL11605095 | 0.70 | RET (0.39) | RETMAPK14CAMK1DHDAC6 | |
| SCHEMBL25442785 | 0.67 | — | — | |
| SCHEMBL4411047 | 0.67 | RET (0.46) | RETMAPK14CAMK1DHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539178-A2 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004017911-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-03-04 | — | — | WO | disclosed |