Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL242407 | 0.79 | NPC1 (0.41) | MAPTKMT2AMEN1L3MBTL1KDM4E | |
| SCHEMBL241448 | 0.79 | MPO (0.40) | MPOMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL13163265 | 0.79 | ALDH1A1 (0.41) | CTSLCTSBMPOMAPTKMT2A | |
| SCHEMBL242223 | 0.79 | NPC1 (0.37) | MPOMAPTKMT2AMEN1KDM4E | |
| SCHEMBL12861068 | 0.75 | ALDH1A1 (0.44) | SRCMPOMAPTKMT2AMEN1 | |
| SCHEMBL13163266 | 0.73 | SMN1; SMN2 (0.43) | MAPTKMT2AMEN1POLBKDM4E | |
| SCHEMBL13993590 | 0.73 | ALDH1A1 (0.38) | MPOMAPTKMT2AMEN1POLB | |
| SCHEMBL13163262 | 0.72 | SMN1; SMN2 (0.40) | MPOMAPTKMT2AMEN1POLB | |
| SCHEMBL243787 | 0.71 | NR4A2 (0.47) | SRCCTSLCTSBMPOMAPT | |
| SCHEMBL3266921 | 0.70 | NPC1 (0.33) | MPOMAPTKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465625-A4 | SOLUBILIZED TOPOISOMERASE POISONS | UNIV RUTGERS (US) | 2005-06-08 | — | — | EP | disclosed |
| EP-1465625-A2 | SOLUBILIZED TOPOISOMERASE POISONS | Rutgers, The State University (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003041660-A2 | SOLUBILIZED TOPOISOMERASE POISONS | RUTGERS, THE STATE UNIVERSITY (US) | 2003-05-22 | — | — | WO | disclosed |