Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10468609 | 0.93 | KMT2A (0.56) | KMT2AMEN1TDP1MAPTHDAC8 | |
| SCHEMBL6318387 | 0.81 | MEN1 (0.51) | KMT2AMEN1TDP1MAPTHDAC8 | |
| SCHEMBL9825954 | 0.81 | MEN1 (0.46) | KMT2AMEN1TDP1MAPTHDAC8 | |
| SCHEMBL6202493 | 0.81 | MAPT (0.60) | KMT2AMEN1MAPTHDAC8CYP19A1 | |
| SCHEMBL10355375 | 0.81 | MEN1 (0.64) | KMT2AMEN1TDP1MAPTCYP19A1 | |
| SCHEMBL6201563 | 0.80 | PPARG (0.43) | KMT2AMEN1TDP1MAPTCYP19A1 | |
| SCHEMBL6202608 | 0.79 | MAPT (0.67) | KMT2AMEN1TDP1MAPTHDAC8 | |
| SCHEMBL10470915 | 0.78 | CYP19A1 (0.50) | KMT2AMEN1TDP1CYP19A1LMNA | |
| SCHEMBL11534459 | 0.77 | MEN1 (0.56) | KMT2AMEN1TDP1HDAC8CYP19A1 | |
| SCHEMBL10731153 | 0.77 | MEN1 (0.59) | KMT2AMEN1TDP1MAPTHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |