Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6319766 | 0.91 | MAPT (0.44) | MAPTKMT2AHTTMDM2CYP19A1 | |
| SCHEMBL6202493 | 0.83 | MAPT (0.60) | PPARGMAPTKMT2ALMNAHTT | |
| SCHEMBL6222574 | 0.81 | CYP19A1 (0.49) | PPARGPPARAMAPTKMT2AMDM2 | |
| SCHEMBL10468609 | 0.81 | KMT2A (0.56) | MAPTKMT2ALMNAHTTCYP19A1 | |
| SCHEMBL6221534 | 0.80 | HPGD (0.45) | MAPTKMT2AHTTMEN1SMN1; SMN2 | |
| SCHEMBL6202771 | 0.80 | KMT2A (0.54) | MAPTKMT2ALMNAHTTCYP19A1 | |
| SCHEMBL10799731 | 0.78 | CYP19A1 (0.48) | MAPTKMT2ALMNAHTTCYP19A1 | |
| SCHEMBL10418945 | 0.77 | HSP90AA1 (0.48) | MAPTKMT2ALMNAHTTCYP19A1 | |
| SCHEMBL10879896 | 0.76 | CYP19A1 (0.49) | PPARGPPARAMAPTKMT2ALMNA | |
| SCHEMBL10364784 | 0.76 | KMT2A (0.54) | MAPTKMT2ALMNAHTTCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |