Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTR1E | P28566 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4992446 | 0.98 | LMNA (0.59) | LMNAMAPTHTR1ENPSR1S1PR3 | |
| SCHEMBL14161396 | 0.96 | LMNA (0.53) | LMNAMAPTHTR1ENPSR1S1PR3 | |
| SCHEMBL171875 | 0.92 | LMNA (0.47) | LMNAMAPTHTR1ENPSR1S1PR3 | |
| Hydrochloric Acid SCHEMBL435506 | 0.90 | OPRM1 (0.46) | LMNAMAPTHTR1ENPSR1S1PR3 | |
| SCHEMBL3416397 | 0.84 | LMNA (0.55) | LMNAMAPTNPSR1ALDH1A1OPRM1 | |
| SCHEMBL8636887 | 0.84 | OPRM1 (0.48) | LMNAKDM4EOPRM1ADRA1DADRA1A | |
| SCHEMBL2443314 | 0.82 | MAPT (0.49) | MAPTHTR1ENPSR1S1PR3AKR1C1 | |
| SCHEMBL8184245 | 0.82 | LMNA (0.54) | LMNAAKR1C1SMN1; SMN2ALDH1A1HDAC4 | |
| SCHEMBL1048151 | 0.82 | AKR1C1 (0.68) | MAPTHTR1ENPSR1S1PR3AKR1C1 | |
| SCHEMBL2817645 | 0.82 | LMNA (0.54) | LMNAAKR1C1SMN1; SMN2ALDH1A1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377589-B1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2005-09-07 | — | — | EP | claimed |