Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 16/20 | 0.62 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5406519 | 0.81 | CRHR1 (0.68) | CRHR1RUNX1 | |
| SCHEMBL6203918 | 0.80 | CRHR1 (0.48) | CRHR1RUNX1CTSA | |
| SCHEMBL5414869 | 0.79 | CRHR1 (0.68) | CRHR1RUNX1CTSA | |
| SCHEMBL5414310 | 0.78 | CRHR1 (0.69) | CRHR1CTSA | |
| SCHEMBL5406545 | 0.77 | CRHR1 (0.70) | CRHR1 | |
| SCHEMBL5406509 | 0.77 | CRHR1 (1.00) | CRHR1 | |
| SCHEMBL5412848 | 0.76 | CRHR1 (0.66) | CRHR1 | |
| SCHEMBL5417192 | 0.75 | CRHR1 (0.62) | CRHR1RUNX1 | |
| SCHEMBL5420378 | 0.74 | CRHR1 (0.63) | CRHR1RUNX1 | |
| SCHEMBL4882817 | 0.73 | CRHR1 (0.59) | CRHR1RUNX1CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | disclosed |