Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 4/20 | 0.48 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203416 | 0.82 | RUNX1 (0.40) | CRHR1RUNX1SCN9ACTSAALPL | |
| SCHEMBL6202812 | 0.80 | CRHR1 (0.62) | CRHR1RUNX1CTSA | |
| SCHEMBL6203375 | 0.80 | CRHR1 (0.45) | CRHR1RUNX1SCN9ACTSA | |
| SCHEMBL5409117 | 0.77 | CRHR1 (0.48) | CRHR1RUNX1SCN9ACTSAALPL | |
| SCHEMBL5417862 | 0.76 | CRHR1 (0.49) | CRHR1RUNX1SCN9A | |
| SCHEMBL7160526 | 0.75 | CRHR1 (0.46) | CRHR1RUNX1SCN9AALDH1A1GAA | |
| SCHEMBL5409112 | 0.74 | CRHR1 (0.50) | CRHR1RUNX1SCN9ACTSAALPL | |
| SCHEMBL5420406 | 0.74 | CRHR1 (0.68) | CRHR1RUNX1SCN9A | |
| SCHEMBL5409786 | 0.73 | CRHR1 (0.47) | CRHR1RUNX1SCN9ACTSAALDH1A1 | |
| SCHEMBL6204014 | 0.73 | RUNX1 (0.40) | CRHR1RUNX1SCN9ACTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | disclosed |
| EP-1255740-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001060806-A2 | SUBSTITUTED ARYLPYRAZINES | NEUROGEN CORPORATION (US) | 2001-08-23 | — | — | WO | disclosed |