Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | CASP3 | P42574 | 1/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.57 |
| ▸ | RELA | Q04206 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6202779 | 0.91 | NPC1 (0.64) | NPC1RAB9AL3MBTL1CASP3SMN1; SMN2 | |
| SCHEMBL6223219 | 0.86 | NPC1 (0.58) | NPC1RAB9AL3MBTL1HDAC4HDAC1 | |
| SCHEMBL2042619 | 0.84 | HDAC1 (0.58) | HSP90AA1NPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL6202120 | 0.81 | NPC1 (0.68) | NPC1RAB9ANFKB1NFKB2RELA | |
| SCHEMBL6198290 | 0.80 | NPC1 (0.65) | NPC1RAB9AL3MBTL1SMN1; SMN2MEN1 | |
| SCHEMBL9490115 | 0.80 | HSP90AA1 (0.71) | HSP90AA1NPC1RAB9AL3MBTL1NFKB1 | |
| SCHEMBL5592824 | 0.80 | PRSS1 (0.68) | NPC1RAB9AL3MBTL1SMN1; SMN2MEN1 | |
| SCHEMBL9422525 | 0.80 | HSP90AA1 (0.91) | HSP90AA1NPC1RAB9ASMN1; SMN2TMEM97 | |
| SCHEMBL3030903 | 0.79 | HSP90AA1 (0.69) | HSP90AA1NPC1RAB9AL3MBTL1NFKB1 | |
| SCHEMBL3034137 | 0.79 | HSP90AA1 (0.65) | HSP90AA1NPC1RAB9AL3MBTL1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |