Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.62 |
| ▸ | NAAA | Q02083 | 1/20 | 0.62 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.59 |
| ▸ | CTSG | P08311 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6223219 | 0.92 | NPC1 (0.58) | NPC1RAB9AL3MBTL1LMNATDP1 | |
| SCHEMBL6202820 | 0.91 | HSP90AA1 (0.65) | NPC1RAB9AL3MBTL1LMNATDP1 | |
| SCHEMBL5592824 | 0.89 | PRSS1 (0.68) | NPC1RAB9AL3MBTL1LMNATDP1 | |
| SCHEMBL7136870 | 0.87 | TDP1 (0.64) | NPC1RAB9AL3MBTL1LMNATDP1 | |
| SCHEMBL2033165 | 0.87 | MAPK1 (0.73) | NPC1RAB9ALMNAHDAC1HDAC8 | |
| SCHEMBL6202120 | 0.87 | NPC1 (0.68) | NPC1RAB9AHDAC1HDAC8HDAC3 | |
| SCHEMBL9491686 | 0.86 | NPC1 (0.75) | NPC1RAB9ALMNAHDAC1HDAC8 | |
| SCHEMBL8779817 | 0.86 | HDAC1 (0.79) | NPC1RAB9ALMNAHDAC1HDAC8 | |
| SCHEMBL6198290 | 0.85 | NPC1 (0.65) | NPC1RAB9AL3MBTL1MAPTHDAC1 | |
| SCHEMBL7769421 | 0.85 | NPC1 (0.64) | NPC1RAB9ALMNAHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| US-6855710-B2 | Substituted indolines with an inhibitory effect on various kinases and complexes of CDKs | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-02-15 | — | — | US | disclosed |
| US-20040058978-A1 | Novel substituted indolines with an inhibitory effect on various kinases and complexes of CDKs | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-03-25 | — | — | US | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058978-A1 | Novel substituted indolines with an inhibitory effect on various kinases and complexes of CDKs | CDK1, CDK2, CDK3 | NPC1 4477/4885RAB9A 2092/4885L3MBTL1 3701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.