Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.53 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 2/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.51 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12221485 | 0.84 | KMT2A (0.61) | MAOBKMT2ASMN1; SMN2MEN1CYP4F2 | |
| SCHEMBL23923495 | 0.84 | KMT2A (0.61) | MAOBKMT2ASMN1; SMN2MEN1CYP4F2 | |
| SCHEMBL31748975 | 0.84 | KMT2A (0.61) | MAOBKMT2ASMN1; SMN2MEN1CYP4F2 | |
| SCHEMBL6203969 | 0.84 | MAOB (0.63) | MAOBKMT2ASMN1; SMN2MEN1CYP4F2 | |
| SCHEMBL5772077 | 0.84 | KMT2A (0.62) | MAOBKMT2ASMN1; SMN2MEN1CYP4F2 | |
| SCHEMBL5911726 | 0.84 | KMT2A (0.62) | MAOBKMT2ASMN1; SMN2MEN1CYP4F2 | |
| SCHEMBL477599 | 0.83 | SMN1; SMN2 (0.62) | MAOBKMT2ASMN1; SMN2MEN1CYP4F2 | |
| SCHEMBL11603161 | 0.83 | KMT2A (0.63) | MAOBKMT2ASMN1; SMN2MEN1CYP4F2 | |
| SCHEMBL6204244 | 0.83 | LMNA (0.58) | MAOBSMN1; SMN2ALOX5LMNANR4A2 | |
| SCHEMBL20604382 | 0.82 | KMT2A (0.62) | MAOBKMT2ASMN1; SMN2MEN1CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |