Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK1 | Q9BQI3 | 5/20 | 0.41 |
| ▸ | PDE5A | O76074 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6202704 | 0.74 | PDGFRB (0.41) | ALDH1A1PKMMAPTPDGFRBL3MBTL1 | |
| SCHEMBL4042770 | 0.73 | KDM4E (0.50) | ALDH1A1CYP1A2CYP2D6TSHRCYP2C19 | |
| SCHEMBL4040923 | 0.73 | EIF2AK1 (0.48) | EIF2AK1ALDH1A1MAPTABL1SRC | |
| SCHEMBL4044820 | 0.71 | EIF2AK1 (0.58) | EIF2AK1ALDH1A1KDM4EMAPTPDGFRB | |
| SCHEMBL4046585 | 0.69 | PDGFRB (0.43) | ALDH1A1KDM4ESMN1; SMN2PDGFRB | |
| SCHEMBL4052068 | 0.68 | EIF2AK1 (0.58) | EIF2AK1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4040728 | 0.67 | CHEK1 (0.42) | EIF2AK1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4040762 | 0.66 | EIF2AK1 (0.56) | EIF2AK1ALDH1A1TSHRKDM4EPDGFRB | |
| SCHEMBL4047538 | 0.65 | CACNA1B (0.39) | PDGFRB | |
| SCHEMBL4051009 | 0.65 | ACHE (0.44) | ALDH1A1CYP1A2CYP3A4CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | claimed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | claimed |