Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 16/20 | 0.68 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.62 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1472764 | 0.83 | IMPDH2 (0.83) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1474411 | 0.81 | IMPDH2 (1.00) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1475788 | 0.81 | IMPDH2 (1.00) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL12749604 | 0.81 | IMPDH2 (0.80) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL7724586 | 0.80 | AAK1 (0.65) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1616816 | 0.80 | AAK1 (0.68) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL4258273 | 0.80 | IMPDH2 (0.80) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL15741713 | 0.79 | IMPDH2 (0.83) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL14518615 | 0.79 | IMPDH2 (0.74) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6488119 | 0.78 | IMPDH2 (0.65) | IMPDH2IMPDH1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1126843-A4 | COMPOUNDS DERIVED FROM AN AMINE NUCLEUS THAT ARE INHIBITORS OF IMPDH ENZYME | BRISTOL MYERS SQUIBB CO (US) | 2005-06-15 | — | — | EP | disclosed |
| US-6399773-B1 | AUTOIMMUNE DISEASE; TRANSPLANTING ORGANS | BRISTOL-MYERS SQUIBB CO. | 2002-06-04 | — | — | US | disclosed |
| EP-1126843-A1 | COMPOUNDS DERIVED FROM AN AMINE NUCLEUS THAT ARE INHIBITORS OF IMPDH ENZYME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000025780-A1 | COMPOUNDS DERIVED FROM AN AMINE NUCLEUS THAT ARE INHIBITORS OF IMPDH ENZYME | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-05-11 | — | — | WO | disclosed |