Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 13/20 | 0.65 |
| ▸ | IMPDH2 | P12268 | 8/20 | 0.64 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1616816 | 0.88 | AAK1 (0.68) | AAK1IMPDH2IMPDH1 | |
| SCHEMBL6168530 | 0.85 | IMPDH2 (0.67) | AAK1IMPDH2IMPDH1 | |
| SCHEMBL12749604 | 0.84 | IMPDH2 (0.80) | AAK1IMPDH2IMPDH1 | |
| SCHEMBL14518599 | 0.83 | IMPDH2 (0.68) | AAK1IMPDH2IMPDH1 | |
| SCHEMBL5531405 | 0.83 | AAK1 (0.75) | AAK1IMPDH2IMPDH1 | |
| SCHEMBL6170236 | 0.83 | AAK1 (0.68) | AAK1IMPDH2IMPDH1 | |
| SCHEMBL14518615 | 0.81 | IMPDH2 (0.74) | AAK1IMPDH2IMPDH1 | |
| SCHEMBL6639762 | 0.81 | IMPDH2 (0.68) | AAK1IMPDH2IMPDH1 | |
| SCHEMBL6202996 | 0.80 | IMPDH2 (0.68) | AAK1IMPDH2IMPDH1 | |
| SCHEMBL6495167 | 0.80 | IMPDH2 (0.79) | AAK1IMPDH2IMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399773-B1 | AUTOIMMUNE DISEASE; TRANSPLANTING ORGANS | BRISTOL-MYERS SQUIBB CO. | 2002-06-04 | — | — | US | disclosed |