Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205082 | 0.83 | SCN9A (0.47) | ALOX5APFEN1NPC1RAB9AKMT2A | |
| SCHEMBL13461 | 0.74 | CES2 (0.65) | FEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL29593208 | 0.74 | CES2 (0.65) | FEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7418290 | 0.73 | CES2 (0.62) | FEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL28925931 | 0.72 | SLC6A3 (0.51) | KMT2ASMN1; SMN2ALDH1A1MEN1MAPT | |
| SCHEMBL1515817 | 0.71 | CES2 (0.50) | ALOX5APFEN1NPC1RAB9AKMT2A | |
| SCHEMBL29169247 | 0.69 | CES2 (0.58) | FEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| Isopropyl Alcohol SCHEMBL29078917 | 0.68 | CES2 (0.56) | FEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| Fluorobenzene SCHEMBL28799844 | 0.68 | CES2 (0.56) | FEN1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL5650569 | 0.67 | SCN9A (0.44) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501834-A1 | TRIARYL-OXY-ARYL-SPIRO-PYRIMIDINE-2, 4, 6-TRIONE METALLOPROTEINASE INHIBITORS | Pfizer Products Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003091259-A1 | TRIARYL-OXY-ARYL-SPIRO-PYRIMIDINE-2, 4, 6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2003-11-06 | — | — | WO | disclosed |