Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.39 |
| ▸ | WNT3A | P56704 | 5/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | CPB1 | P15086 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25440347 | 0.75 | CNR2 (0.44) | CNR2PARP1NPC1ADORA2AADORA1 | |
| SCHEMBL20242216 | 0.66 | MPL (0.51) | PARP1NPC1RAB9AFEN1ADORA2A | |
| SCHEMBL14637421 | 0.66 | MPL (0.47) | PARP1NPC1RAB9A | |
| SCHEMBL20385737 | 0.66 | ENPP3 (0.51) | NPC1RAB9A | |
| SCHEMBL1515749 | 0.66 | PTPN1 (0.59) | CNR2NPC1RAB9APTPN1ERCC5 | |
| SCHEMBL8867252 | 0.66 | ALDH1A1 (0.63) | CNR2NPC1RAB9APTPN1ERCC5 | |
| SCHEMBL28071327 | 0.65 | KDM4E (0.45) | NPC1RAB9APTPN1ERCC5FEN1 | |
| SCHEMBL30089515 | 0.65 | CTNNB1 (0.68) | NPC1PTPN1ERCC5FEN1CTNNB1 | |
| SCHEMBL20508992 | 0.65 | PTPN1 (0.74) | NPC1RAB9APTPN1ERCC5FEN1 | |
| SCHEMBL13335153 | 0.64 | AKR1B1 (0.59) | CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501834-A1 | TRIARYL-OXY-ARYL-SPIRO-PYRIMIDINE-2, 4, 6-TRIONE METALLOPROTEINASE INHIBITORS | Pfizer Products Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003091259-A1 | TRIARYL-OXY-ARYL-SPIRO-PYRIMIDINE-2, 4, 6-TRIONE METALLOPROTEINASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2003-11-06 | — | — | WO | disclosed |