Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 15/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6202949 | 0.99 | CRHR1 (0.46) | CRHR1LRRK2SCN9ACYP3A4SPR | |
| SCHEMBL6202172 | 0.99 | CRHR1 (0.46) | CRHR1LRRK2SCN9ACYP3A4SPR | |
| SCHEMBL6203641 | 0.89 | CRHR1 (0.56) | CRHR1LRRK2SCN9ACYP3A4 | |
| SCHEMBL6204123 | 0.88 | CRHR1 (0.56) | CRHR1LRRK2SCN9ACYP3A4 | |
| SCHEMBL6202311 | 0.88 | CRHR1 (0.56) | CRHR1LRRK2SCN9ACYP3A4 | |
| SCHEMBL6203243 | 0.87 | CRHR1 (0.48) | CRHR1SCN9A | |
| SCHEMBL6202901 | 0.86 | CRHR1 (0.47) | CRHR1SCN9A | |
| SCHEMBL6203602 | 0.84 | CRHR1 (0.45) | CRHR1LRRK2 | |
| SCHEMBL5431307 | 0.83 | CRHR1 (0.48) | CRHR1LRRK2SCN9A | |
| SCHEMBL5434414 | 0.83 | CRHR1 (0.52) | CRHR1LRRK2SCN9ACYP3A4SPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | claimed |