Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 7/20 | 0.45 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204985 | 0.99 | CRHR1 (0.44) | CRHR1CACNA2D1LRRK2THRATHRB | |
| SCHEMBL6202389 | 0.99 | CRHR1 (0.44) | CRHR1CACNA2D1LRRK2THRATHRB | |
| SCHEMBL5446474 | 0.92 | CRHR1 (0.49) | CRHR1CACNA2D1LRRK2MAPTATM | |
| SCHEMBL6203048 | 0.89 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL6204012 | 0.89 | CRHR1 (0.45) | CRHR1CACNA2D1LRRK2MAPTTHRA | |
| SCHEMBL6203200 | 0.88 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL6202607 | 0.88 | CRHR1 (0.46) | CRHR1THRATHRB | |
| SCHEMBL6204280 | 0.88 | CRHR1 (0.46) | CRHR1THRATHRB | |
| SCHEMBL6203243 | 0.88 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL6204277 | 0.88 | CRHR1 (0.45) | CRHR1CACNA2D1LRRK2THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | claimed |