Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 3/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6085567 | 0.89 | PTPN2 (0.42) | PTPN2PTPN1PTPN5MAPTLMNA | |
| SCHEMBL6086910 | 0.88 | HSP90AA1 (0.39) | LMNATP53ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL6085573 | 0.85 | BRD4 (0.42) | PTPN2PTPN1PTPN5LMNAALDH1A1 | |
| SCHEMBL6085797 | 0.82 | NPC1 (0.42) | MAPTTP53POLBALDH1A1KDM4E | |
| SCHEMBL6084819 | 0.81 | ALDH1A1 (0.44) | MAPTLMNATP53POLBALDH1A1 | |
| SCHEMBL6085204 | 0.80 | PTPN1 (0.61) | PTPN2PTPN1PTPN5MAPTLMNA | |
| SCHEMBL6084903 | 0.79 | MEN1 (0.44) | MAPTLMNATP53POLBALDH1A1 | |
| SCHEMBL6200297 | 0.79 | PTPN1 (0.63) | PTPN2PTPN1PTPN5MAPTLMNA | |
| SCHEMBL6202869 | 0.79 | MAPT (0.58) | PTPN2PTPN1PTPN5MAPTLMNA | |
| SCHEMBL6086056 | 0.78 | POLB (0.44) | LMNAPOLBALDH1A1USP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377589-B1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2005-09-07 | — | — | EP | claimed |