Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | FLT1 | P17948 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23014338 | 0.86 | RAB9A (0.52) | MAPTCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL14597973 | 0.84 | NPC1 (0.58) | POLBMAPTCYP1A2HPGDRAB9A | |
| SCHEMBL11380224 | 0.83 | POLB (0.64) | POLBTHRBRECQLTDP1L3MBTL1 | |
| SCHEMBL9009113 | 0.82 | MEN1 (0.56) | POLBMAPTCYP1A2CYP2D6CYP2C9 | |
| SCHEMBL8858800 | 0.80 | KMT2A (0.61) | MAPTCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL23014171 | 0.80 | CYP1A2 (0.53) | POLBTHRBRECQLTDP1L3MBTL1 | |
| SCHEMBL23014479 | 0.80 | KMT2A (0.73) | L3MBTL1MAPTCYP1A2CYP2C9RAB9A | |
| SCHEMBL5031842 | 0.79 | KDM4E (0.68) | POLBTHRBRECQLTDP1L3MBTL1 | |
| SCHEMBL11472681 | 0.79 | ERCC5 (0.62) | TDP1MAPTKDM4EHPGDRAB9A | |
| SCHEMBL23014498 | 0.78 | GPR139 (0.58) | TDP1MAPTKDM4EHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |