Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.39 |
| ▸ | KRAS | P01116 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6291709 | 0.80 | IDO1 (0.44) | IDO1TDO2ALDH1A1MAPK1MBTD1 | |
| SCHEMBL30608097 | 0.79 | IDO1 (0.47) | IDO1TDO2ALDH1A1MAPK1MBTD1 | |
| SCHEMBL511201 | 0.79 | IDO1 (0.47) | IDO1TDO2ALDH1A1MAPK1MBTD1 | |
| SCHEMBL27273704 | 0.78 | ACHE (0.44) | IDO1ALDH1A1MAPK1SOS1 | |
| SCHEMBL28741804 | 0.77 | ALDH1A1 (0.44) | IDO1TDO2ALDH1A1MAPK1MBTD1 | |
| SCHEMBL11138739 | 0.77 | ALDH1A1 (0.44) | IDO1TDO2ALDH1A1MAPK1MBTD1 | |
| SCHEMBL29427056 | 0.76 | ALDH1A1 (0.48) | IDO1TDO2ALDH1A1MAPK1MBTD1 | |
| SCHEMBL135394 | 0.76 | ALDH1A1 (0.48) | IDO1TDO2ALDH1A1MAPK1MBTD1 | |
| SCHEMBL6202388 | 0.76 | IDO1 (0.44) | IDO1TDO2 | |
| SCHEMBL10861290 | 0.76 | AOC3 (0.42) | SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |