Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 19/20 | 0.56 |
| ▸ | MMP14 | P50281 | 8/20 | 0.56 |
| ▸ | MMP12 | P39900 | 5/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5935746 | 1.00 | MMP13 (0.56) | MMP13MMP14MMP12ADAM17 | |
| SCHEMBL5935714 | 0.92 | ADAM17 (0.51) | MMP13MMP14MMP12ADAM17 | |
| SCHEMBL5935633 | 0.88 | MMP13 (0.51) | MMP13MMP14MMP12ADAM17 | |
| SCHEMBL5935622 | 0.88 | ADAM17 (0.46) | MMP13MMP14ADAM17 | |
| SCHEMBL5935655 | 0.83 | ADAM17 (0.45) | MMP13MMP12ADAM17 | |
| SCHEMBL5935705 | 0.83 | MMP13 (0.52) | MMP13MMP14MMP12ADAM17 | |
| SCHEMBL5935630 | 0.81 | MMP13 (0.49) | MMP13MMP14MMP12 | |
| SCHEMBL5935740 | 0.80 | MMP13 (0.57) | MMP13MMP14MMP12 | |
| SCHEMBL941844 | 0.80 | MMP13 (0.57) | MMP13MMP14MMP12 | |
| SCHEMBL5935747 | 0.79 | ADAM17 (0.52) | MMP13MMP12ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539706-A1 | 1-SULPHONYL PIPERIDINE DERIVATIVES | AstraZeneca AB (SE) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004024698-A1 | 1-SULPHONYL PIPERIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-03-25 | — | — | WO | disclosed |