Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206927 | 0.88 | HPGD (0.37) | RAB9AKMT2AHPGDPOLBRAD52 | |
| SCHEMBL27641101 | 0.75 | — | — | |
| SCHEMBL6203472 | 0.70 | ALOX5 (0.34) | ALOX5PTGS1PTGS2HDAC4TRPM8 | |
| SCHEMBL9055451 | 0.70 | NPC1 (0.41) | PTGS1PTGS2RAB9AHPGDPOLB | |
| Benzene SCHEMBL7938846 | 0.67 | NPC1 (0.33) | RAB9AKMT2AHPGD | |
| SCHEMBL2906792 | 0.67 | — | — | |
| SCHEMBL24163162 | 0.65 | HSP90AA1 (0.53) | RAB9ATRPM8HPGD | |
| SCHEMBL14518464 | 0.65 | HDAC4 (0.51) | HDAC4KMT2AHPGDMEN1 | |
| Benzene SCHEMBL5373706 | 0.64 | NPC1 (0.42) | RAB9AKMT2AHPGDMEN1 | |
| SCHEMBL3648506 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532132-A1 | NOVEL BENZODIOXOLES | F.HOFFMANN-LA ROCHE AG (CH) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004013120-A1 | NOVEL BENZODIOXOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-02-12 | — | — | WO | disclosed |