Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 3/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | BRS3 | P32247 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15160167 | 0.81 | PPARG (0.43) | MAOBPPARGALDH1A1BRS3LMNA | |
| SCHEMBL6201445 | 0.81 | LMNA (0.64) | TAAR1ACHEALDH1A1LMNATDP1 | |
| SCHEMBL15493030 | 0.79 | PPARG (0.41) | MAOBPPARGBRS3LMNATDP1 | |
| SCHEMBL15158641 | 0.78 | PPARG (0.41) | MAOBPPARGBRS3LMNATDP1 | |
| SCHEMBL257992 | 0.77 | MAOB (0.55) | MAOBLTA4HALDH1A1LMNATDP1 | |
| SCHEMBL30098542 | 0.77 | MAOB (0.55) | MAOBLTA4HALDH1A1LMNATDP1 | |
| SCHEMBL4374778 | 0.77 | ST14 (0.55) | MAOB | |
| SCHEMBL8736450 | 0.77 | LYN (0.60) | ACHEALDH1A1LMNATDP1 | |
| SCHEMBL415399 | 0.76 | TAAR1 (0.65) | TAAR1MAOBACHELTA4HPLA2G2A | |
| SCHEMBL6201328 | 0.76 | TAAR1 (0.56) | TAAR1MAOBACHELMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581498-A2 | PYRIDINYL, PYRIMIDINYL AND PYRAZINYL AMIDES AS POTASSIUM CHANNEL OPENERS | Bristol-Myers Squibb Company (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004047739-A2 | PYRIDINYL, PYRIMIDINYL AND PYRAZINYL AMIDES AS POTASSIUM CHANNEL OPENERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |