Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 7/20 | 0.56 |
| ▸ | ACHE | P22303 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6201445 | 0.86 | LMNA (0.64) | TAAR1ACHELMNATDP1DRD2 | |
| SCHEMBL6204785 | 0.82 | TAAR1 (0.57) | TAAR1ACHEDRD2DRD1CHRNA7 | |
| SCHEMBL415399 | 0.81 | TAAR1 (0.65) | TAAR1ACHEDRD2DRD1MAOB | |
| Hydrochloric Acid SCHEMBL5356526 | 0.80 | TAAR1 (0.62) | TAAR1ACHEMAOBHTR2CHTR6 | |
| SCHEMBL29102430 | 0.77 | TAAR1 (0.86) | TAAR1MAOB | |
| SCHEMBL30631696 | 0.77 | TAAR1 (0.86) | TAAR1MAOB | |
| SCHEMBL6203524 | 0.76 | TAAR1 (0.50) | TAAR1ACHECHRNA7MAOB | |
| SCHEMBL6203586 | 0.76 | TAAR1 (0.54) | TAAR1ACHELMNATDP1MAOB | |
| SCHEMBL6199971 | 0.75 | TAAR1 (0.62) | TAAR1ACHEDRD2DRD1MAOB | |
| SCHEMBL5947233 | 0.73 | CYP1A2 (0.51) | TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581498-A2 | PYRIDINYL, PYRIMIDINYL AND PYRAZINYL AMIDES AS POTASSIUM CHANNEL OPENERS | Bristol-Myers Squibb Company (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004047739-A2 | PYRIDINYL, PYRIMIDINYL AND PYRAZINYL AMIDES AS POTASSIUM CHANNEL OPENERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |