Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 7/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6202607 | 1.00 | CRHR1 (0.46) | CRHR1SMPD1THRATHRBPLA2G4B | |
| SCHEMBL6203048 | 0.99 | CRHR1 (0.46) | CRHR1SMPD1 | |
| SCHEMBL6203198 | 0.92 | CRHR1 (0.42) | CRHR1SMPD1THRATHRB | |
| SCHEMBL6203200 | 0.91 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL6203571 | 0.90 | CRHR1 (0.46) | CRHR1THRATHRBPLA2G4B | |
| SCHEMBL6204658 | 0.90 | CRHR1 (0.46) | CRHR1THRATHRBPLA2G4B | |
| SCHEMBL6204985 | 0.89 | CRHR1 (0.44) | CRHR1SMPD1THRATHRB | |
| SCHEMBL6202389 | 0.89 | CRHR1 (0.44) | CRHR1SMPD1THRATHRB | |
| SCHEMBL6203227 | 0.89 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL6203602 | 0.88 | CRHR1 (0.45) | CRHR1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | claimed |