SCHEMBL6203776

SCHEMBL6203776

CCCN(CO)c1nc(Nc2cccc(Cl)c2)c2c(n1)N(C(C)C)NN2C(C)C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK5 Q00535 5/20 0.46
CDK5R1 Q15078 4/20 0.46
ATM Q13315 1/20 0.46
CDK1 P06493 7/20 0.39
KDM4E B2RXH2 5/20 0.39
CCNB1 P14635 4/20 0.39
MAPT P10636 3/20 0.39
CCNB2 O95067 3/20 0.39
CCNB3 Q8WWL7 3/20 0.39
SRC P12931 3/20 0.39
MAPK1 P28482 2/20 0.39
CCNE2 O96020 2/20 0.39
CCNE1 P24864 2/20 0.39
CDK2 P24941 2/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
PAK4 O96013 1/20 0.39
ALDH1A1 P00352 1/20 0.39
TP53 P04637 1/20 0.39
CYP1A2 P05177 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6205631 0.89 CCNE2 (0.44) CDK5CDK5R1ATMCDK1CCNE2
SCHEMBL6206176 0.84 CDK5 (0.49) CDK5CDK5R1ATMCDK1KDM4E
SCHEMBL6203210 0.84 CCNE2 (0.42) CDK5CDK5R1ATMCDK1KDM4E
SCHEMBL6206198 0.83 CCNE2 (0.46) CDK1CCNE2CCNE1CDK2HTR2C
SCHEMBL3446259 0.78 CDK1 (0.61) CDK5CDK5R1CDK1KDM4ECCNB1
SCHEMBL6205006 0.77 CDK1 (0.44) CDK5CDK5R1CDK1CCNB1CCNE2
SCHEMBL3444962 0.77 CDK5 (0.61) CDK5CDK5R1CDK1KDM4ECCNB1
SCHEMBL6204092 0.77 CCNT1 (0.31) CDK5CDK5R1CCNE1CDK2
SCHEMBL3444469 0.76 CDK1 (0.46) CDK5CDK5R1CDK1KDM4ECCNB1
SCHEMBL6203902 0.75 CCNE2 (0.31) CCNE2CCNE1CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1539760-A2 AZAPURINE DERIVATIVES INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) 2005-06-15 EP claimed
WO-2004018473-A2 AZAPURINE DERIVATIVES INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) 2004-03-04 WO claimed
EP-1539760-A2 AZAPURINE DERIVATIVES INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) 2005-06-15 EP disclosed
WO-2004018473-A2 AZAPURINE DERIVATIVES INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) 2004-03-04 WO disclosed