Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 9/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.44 |
| ▸ | CDK2 | P24941 | 10/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 7/20 | 0.41 |
| ▸ | PDE5A | O76074 | 3/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.37 |
| ▸ | PDE6C | P51160 | 2/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.36 |
| ▸ | CDK7 | P50613 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNH | P51946 | 1/20 | 0.35 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204543 | 0.87 | CCNE1 (0.37) | CDK1CDK5CDK2CCNE1CCNE2 | |
| SCHEMBL6205415 | 0.87 | CDK1 (0.34) | CDK1CDK5CDK2CCNE1CCNE2 | |
| SCHEMBL6205631 | 0.86 | CCNE2 (0.44) | CDK1CDK5CDK2CCNE1CCNE2 | |
| SCHEMBL6201113 | 0.83 | CDK1 (0.46) | CDK1CDK5CDK2CCNE1CCNE2 | |
| SCHEMBL6203902 | 0.82 | CCNE2 (0.31) | CDK2CCNE1CCNE2 | |
| SCHEMBL6204991 | 0.81 | PKM (0.42) | CDK2CCNE1CCNE2CDK9CCNT1 | |
| SCHEMBL6204186 | 0.80 | PDE5A (0.36) | CDK1CDK5CDK2CCNE1CCNE2 | |
| SCHEMBL6204092 | 0.80 | CCNT1 (0.31) | CDK5CDK2CCNE1CDK7CDK9 | |
| SCHEMBL6206198 | 0.78 | CCNE2 (0.46) | CDK1CDK2CCNE1CCNE2 | |
| SCHEMBL6203776 | 0.77 | CDK5 (0.46) | CDK1CDK5CDK2CCNE1CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539760-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004018473-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2004-03-04 | — | — | WO | disclosed |