Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 11/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.50 |
| ▸ | PRKG1 | Q13976 | 9/20 | 0.50 |
| ▸ | PRKACA | P17612 | 6/20 | 0.50 |
| ▸ | GSK3A | P49840 | 6/20 | 0.50 |
| ▸ | GSK3B | P49841 | 6/20 | 0.50 |
| ▸ | PRKX | P51817 | 5/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.50 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.50 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.50 |
| ▸ | SGK2 | Q9HBY8 | 4/20 | 0.50 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.50 |
| ▸ | CDK2 | P24941 | 3/20 | 0.50 |
| ▸ | AKT2 | P31751 | 3/20 | 0.50 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.50 |
| ▸ | HIPK4 | Q8NE63 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.50 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6497420 | 1.00 | ROCK2 (0.50) | ROCK2ROCK1PRKG1PRKACAGSK3A | |
| SCHEMBL6226878 | 0.88 | LMNA (0.47) | ROCK2ROCK1PRKG1PRKACAGSK3A | |
| SCHEMBL6226884 | 0.88 | LMNA (0.47) | ROCK2ROCK1PRKG1PRKACAGSK3A | |
| SCHEMBL6201813 | 0.87 | ACACB (0.46) | ROCK2ROCK1PRKG1PRKACAGSK3A | |
| SCHEMBL6201803 | 0.87 | ACACB (0.46) | ROCK2ROCK1PRKG1PRKACAGSK3A | |
| SCHEMBL6202188 | 0.86 | MEN1 (0.47) | ROCK2ROCK1PRKG1PRKACAGSK3A | |
| SCHEMBL6485057 | 0.86 | MEN1 (0.47) | ROCK2ROCK1PRKG1PRKACAGSK3A | |
| SCHEMBL6485458 | 0.83 | ROCK1 (0.44) | ROCK2ROCK1PRKG1PRKACAGSK3A | |
| SCHEMBL6202758 | 0.83 | ROCK1 (0.44) | ROCK2ROCK1PRKG1PRKACAGSK3A | |
| SCHEMBL6487046 | 0.83 | ACACB (0.44) | ROCK2ROCK1PRKG1PRKACAGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581498-A2 | PYRIDINYL, PYRIMIDINYL AND PYRAZINYL AMIDES AS POTASSIUM CHANNEL OPENERS | Bristol-Myers Squibb Company (US) | 2005-10-05 | — | — | EP | disclosed |
| US-6900210-B2 | Pyridinyl, pyrimidinyl and pyrazinyl amides as potassium channel openers | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-05-31 | — | — | US | disclosed |
| WO-2004047739-A2 | PYRIDINYL, PYRIMIDINYL AND PYRAZINYL AMIDES AS POTASSIUM CHANNEL OPENERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-10 | — | — | WO | disclosed |
| US-20040102449-A1 | Pyridinyl, pyrimidinyl and pyrazinyl amides as potassium channel openers | BRISTOL-MYERS SQUIBB COMPANY | 2004-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040102449-A1 | Pyridinyl, pyrimidinyl and pyrazinyl amides as potassium channel openers | KCNQ5, KCNQ2, KCNQ3 | ROCK2 3350/4885ROCK1 3191/4885PRKG1 2471/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.