Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 9/20 | 0.61 |
| ▸ | MAOA | P21397 | 5/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.58 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | CDK4 | P11802 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | CCND1 | P24385 | 1/20 | 0.56 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | TLR4 | O00206 | 1/20 | 0.52 |
| ▸ | TLR2 | O60603 | 1/20 | 0.52 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.48 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204379 | 0.81 | CHRM5 (0.53) | TDP1 | |
| SCHEMBL27252705 | 0.81 | MAOB (0.74) | MAOBMAOALCKCYP4F2CYP4A11 | |
| SCHEMBL5545087 | 0.80 | MAOB (0.71) | MAOBMAOALCKCCNB2CDK1 | |
| SCHEMBL28272115 | 0.77 | MAOB (0.63) | MAOBMAOACYP4F2CYP4A11BCHE | |
| SCHEMBL9434803 | 0.77 | LCK (0.72) | MAOBMAOALCKCCNB2CDK1 | |
| SCHEMBL9434794 | 0.77 | LCK (0.72) | MAOBMAOALCKCCNB2CDK1 | |
| SCHEMBL5410674 | 0.77 | TRPA1 (0.39) | MAOBALDH1A1 | |
| SCHEMBL14572077 | 0.77 | MAOB (0.61) | MAOBMAOALCKCCNB2CDK1 | |
| SCHEMBL2265668 | 0.76 | MAOB (0.71) | MAOBMAOALCKCCNB2CDK1 | |
| SCHEMBL29454637 | 0.76 | MAOB (1.00) | MAOBMAOALCKCCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1668601-A | N-substituted tricyclic 3-aminopyrazoles as PDFG receptor inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2005-09-14 | — | — | CN | disclosed |
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |