Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 11/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203740 | 0.86 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL6199780 | 0.83 | CRHR1 (0.40) | CRHR1ACP1 | |
| SCHEMBL5441653 | 0.82 | CRHR1 (0.58) | CRHR1 | |
| SCHEMBL7472159 | 0.76 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL6203783 | 0.76 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL6202690 | 0.74 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL6074443 | 0.73 | CRHR1 (0.65) | CRHR1 | |
| SCHEMBL6203447 | 0.72 | TLR7 (0.38) | CRHR1 | |
| SCHEMBL6203698 | 0.72 | CRHR1 (0.37) | CRHR1 | |
| SCHEMBL7484320 | 0.70 | CRHR1 (0.50) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | claimed |