Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 10/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204026 | 0.83 | CRHR1 (0.41) | CRHR1ACP1 | |
| SCHEMBL6203740 | 0.83 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL5473723 | 0.82 | CRHR1 (0.55) | CRHR1 | |
| SCHEMBL6204586 | 0.74 | USP8 (0.43) | CRHR1POLBALOX15 | |
| SCHEMBL7472159 | 0.73 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL6203800 | 0.73 | CRHR1 (0.39) | CRHR1POLBALOX15 | |
| SCHEMBL6204612 | 0.72 | POLB (0.39) | CRHR1POLB | |
| SCHEMBL6074443 | 0.70 | CRHR1 (0.65) | CRHR1CNR1 | |
| SCHEMBL7484320 | 0.67 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL5432945 | 0.67 | CRHR1 (0.79) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | claimed |