Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3743698 | 0.79 | AOC3 (0.53) | AOC3KDM4EHDAC4HDAC7HDAC5 | |
| SCHEMBL792133 | 0.79 | IDO1 (0.56) | AOC3KDM4EHDAC4HDAC7HDAC5 | |
| SCHEMBL6204937 | 0.79 | CES2 (0.38) | AOC3KDM4EIDO1TDO2CES2 | |
| SCHEMBL15854161 | 0.78 | AOC3 (0.56) | AOC3KDM4EHDAC4HDAC7HDAC5 | |
| SCHEMBL17112350 | 0.78 | AOC3 (0.56) | AOC3KDM4EHDAC4HDAC7HDAC5 | |
| SCHEMBL6205041 | 0.78 | IDO1 (0.46) | IDO1TDO2 | |
| SCHEMBL5168017 | 0.78 | AOC3 (0.49) | AOC3ACHE | |
| SCHEMBL14018507 | 0.77 | AOC3 (0.47) | AOC3KDM4EHDAC4HDAC7HDAC5 | |
| SCHEMBL1046557 | 0.77 | HDAC4 (0.48) | AOC3KDM4EHDAC4HDAC7HDAC5 | |
| SCHEMBL792296 | 0.76 | ACHE (0.48) | AOC3HDAC4HDAC7HDAC5IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101910178-A | Gamma secretase modulators | SCHERING CORP | 2010-12-08 | — | — | CN | disclosed |
| CN-1668601-A | N-substituted tricyclic 3-aminopyrazoles as PDFG receptor inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2005-09-14 | — | — | CN | disclosed |
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |